Chirality matters!
An innovative tool to drive self-assembly
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Unzipping the role of chirality - RSC
Amino acid chirality was only recently identified as a key tool to drive peptide self-assembly into nanostructures and hydrogels.

In the video on the left you can see how only the tripeptide that contains both D and L amino acids (i.e., DLFF) instantly forms a hydrogel at neutral pH, while its  L-analogue (i.e., LFF)  does not.

For more info on this work click on the button links:

Nanostructures observed by transmission electron microscopy (scale bar = 100 nm)

We are exploring the space of amino acid chirality to identify the key principles for the design of self-assembling peptides, soft matter, and smart functional systems.

This class of hydrogels has a range of applications for cell culture, therapy, and much more.

cells on peptide hydrogel

As we make new discoveries, we will update the website.

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